Xcvii. the Synthesis of the Antineuritic Factor
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چکیده
THERE has been some uncertainty as to whether yeast could synthesise vitamin B when grown on a medium which did not contain it. Macdonald [1922], Heller [1923], and Nelson, Fullmer and Cessna [1921] tested for the factor promoting growth in rats and found it present. Harden and Zilva [1921] and Heller [1923] tested for the antineuritic factor, and found this to be synthesised. But Eijkman, Hoogenhuijze and Derks [1922] found that the antineuritic factor did not occur in yeast unless the medium contained either it or its decomposition products. In all these experiments there seems to have been no test at the end as to the success of the precautions against bacterial contamination, although it is known that some species of bacteria can synthesise vitamin B [Damon, 1923; Heller, Elroy and Garbeck, 1925]. In some of the experiments it is almost certain that unsuspected impurities containing bios were present [Hoet, le Clef and Delrue, 1924; Funk and Freedman, 1923; Willaman and Olsen, 1923]. Hence further experiments were undertaken to investigate whether yeast could synthesise the antineuritic factor, if the possibility of active impurities in the medium and of bacterial contamination was excluded or controlled. The antineuritic factor is considered here to be the factor curative for symptoms of head retraction in pigeons fed upon polished rice.
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